DNA origami for synthetic immunology
Mai Tran – Hector RCD Awardee Kerstin Göpfrich
Monomeric or particle-based multimeric subunit vaccines are widely used to induce humoral immune responses that protect from disease. However, how antigen valency and spacing affects B cell activation and antibody production is not well understood. Using a malaria vaccine antigen as model, the project combines DNA-origami-based experimental work with mathematical modeling to define how the biophysical parameters of antigen presentation and antibody affinity affect B cell activation.
The detailed project description will be published here soon.
Mai TranMax Planck Institute for Medical Research, Heidelberg
Kerstin GöpfrichPhysics, Chemistry, Biology, Engineering & Medicine
Hector RCD Awardee since 2021