Accommodation Behavior and Ciliary Muscle Activity in Myopia
Sandra Wagner – Hector Fellow Eberhart Zrenner
Prevalence of myopia (shortsightedness) increases considerably in industrialized countries. The mechanisms behind this development need to be fully understood in order to attain prevention. Research has previously provided indications supporting a possible link between myopia onset and near vision. The process of changing the eye lens’ refractive power to adapt to different viewing distances, referred to as accommodation, is initiated by the ciliary muscle.
This PhD project, supervised by Hector Fellow Eberhart Zrenner, compared the accommodation system of young adults with myopia and emmetropia (normal sightedness) regarding changes in both crystalline lens power and ciliary muscle morphology during regular and sustained accommodation. Furthermore, the possibility to voluntarily control accommodation using auditory biofeedback training was assessed.
Investigations of the ciliary muscle’s anatomy were realized using the imaging technique of optical coherence tomography (see Figure), and a new approach to evaluate morphologic changes during the muscle’s contraction was developed. This tool will lay the scientific foundation for understanding how the ciliary muscle’s anatomical changes may correlate with the neuronal signals controlling its activity.
Findings derived from this project will allow a better understanding of accommodation, address unanswered question regarding myopia onset, and support the development of new devices.
Image of ciliary muscle (marked in red) during near accommodation in a young adult
subject using optical coherence tomography
Sandra WagnerEberhard Karls University of Tübingen
Eberhart ZrennerMedicine, Biology & Engineering
Hector Fellow since 2012