Creat­ing the Future
Projects

Quantum infor­ma­tion process­ing with scalable semicon­duc­tor spin-qubit chips

Dominic Barthlott - Hector Fellow Wolfgang Wernsdorfer

Quantum computing has the potential to provide speedups for classical problems such as complex simulation, optimization and cryptography tasks, but requires scalable and reliable qubit technologies. Semiconductor spin qubits combine long coherence times with established industrial fabrication techniques. This project focusses on implementing high-fidelity two-qubit gates, which are then expanded to multi-qubit arrays and quantified by applying quantum information algorithms together with rigorous benchmarking.

© Dominic Barthlott

Beyond the Cortex: Subcor­ti­cal Connec­tiv­ity in Social Cognition

Lorenz Ahle - Hector RCD Awardee Sofie Valk

This project explores how subcortical structures such as the amygdala, thalamus, basal ganglia, cerebellum and hippocampus shape social cognition. Using high-resolution fMRI, diffusion MRI and computational modeling it examines how connections between subcortex and cortex support empathy, perspective taking and emotional regulation.

© Sofie Valk

Neural mecha­nisms of visual percep­tual learn­ing in children and adults

Dominik Aschenbrenner - Hector RCD Awardee Sebastian Frank

Visual perceptual learning (VPL) – a type of visual skill learning – has often been studied in adults as a model system to identify neural mechanisms of learning. However, it is unclear whether children employ similar neural mechanisms for VPL as adults. In this project, we will use non-invasive brain imaging to measure and compare neural mechanisms of VPL in children and adults and examine whether and if so how learning changes from childhood to adulthood.

© Dominik Aschenbrenner

Synthe­sis and Charac­ter­i­za­tion of biofunc­tion­al­ized organ­otin chalco­genide clusters

Martina Kämpfe - Hector Fellow Stefanie Dehnen

The cytotoxicity of organic tin compounds makes them interesting for cancer chemotherapy. Organotin chalcogenide clusters release under acidic decomposition not only an organic tin compound but also an even more toxic hydrogen chalcogenide. To enable biocompatibility of those clusters, they must be derivatized with biomolecules. This project aims to synthesize biofunctionalized organotin chalcogenide clusters and to investigate their decomposition behavior.

© Martina Kämpfe

Mecha­nisms of mitochon­dr­ial protein translo­ca­tion and membrane biogenesis

Pragya Kaushik - Hector Fellow Nikolaus Pfanner

Mitochondrial protein import is mediated by the presequence translocase of the inner membrane (TIM23 complex). While Tim17 is central for inner membrane translocation, the exact role of Mgr2, a small transmembrane protein, remains unclear. This project aims to define the function of Mgr2 in precursor protein import, membrane insertion, and translocase stability using genetic, biochemical, and structural approaches.

© Pragya Kaushik

CRISPR/Cas and RNA Thera­peu­tics for Inher­ited Retinal Diseases

Pietro De Angeli - Hector Fellow Eberhart Zrenner

Vision loss from inherited retinal diseases is caused by faulty genes. My research uses cutting-edge tools—like CRISPR and RNA therapies—to fix or silence mutations in genes such as RHO, USH2A, and ABCA4. These treatments are tested in advanced patient-derived models, including iPSC-derived retinal cells, with the goal of developing safe, effective therapies ready for clinical translation.

© Pietro De Angeli