Mechanisms of mitochondrial protein translocation and membrane biogenesis
Pragya Kaushik - Hector Fellow Nikolaus Pfanner
Mitochondrial protein import is mediated by the presequence translocase of the inner membrane (TIM23 complex). While Tim17 is central for inner membrane translocation, the exact role of Mgr2, a small transmembrane protein, remains unclear. This project aims to define the function of Mgr2 in precursor protein import, membrane insertion, and translocase stability using genetic, biochemical, and structural approaches.









