Neuroimmune-vascular interplay in Alzheimer’s disease
Matteo Rovere - Hector Fellow Christian Haass
Alzheimer’s disease (AD) has a multifactorial etiology which includes, among others, vascular dysfunction and aberrant neuroimmunity. We aim to investigate the gene ABI3 as a potential connection between these two facets of AD pathophysiology. Through transgenic murine models, and using a combination of biochemical, immunohistochemical, and in vivo imaging techniques, we will explore how the late-onset AD risk variant S209F ABI3 affects neurodegeneration, immune fitness, and vascular dynamics.